QUANTUM^® Cell Expansion System

The Quantum^® Cell Expansion System is an automated cell culture platform that can help simplify the open, labor-intensive manual tasks associated with flask-based culture.

The Quantum system helps support your ability to consistently produce a safe and effective cellular therapy through:

• Expansion of adherent and suspension cells, as well as plasmid transfections and viral transductions
• Cell doubling times and cell quality comparable to manual flask-based culture
• Production of cells with consistent yields and cell quality
• Maintaining cell characteristics consistent with flasks
• Stable cell culture environment for both hypoxic and normoxic conditions
• Software features aid in Part 11 current Good Manufacturing Practices (cGMP) compliance

Enable reproducible, scalable processes:

When comparing mesenchymal stromal cell production in flasks versus the Quantum^® Cell Expansion System, automation showed an 88% reduction in harvest time and labor hours.²

Reduce variables in the work path and improve efficiency:

Use of an automated bioreactor closed system has been shown to increase yields and reduce growing times for a variety of cell types. In one report, City of Hope generated a GMP-grade lot of clinically viable neural stem cells within nine days with Quantum, compared with six weeks using cell factories.¹

Reduce open events with a closed cell culture environment:

The closed environment of the bioreactor remains intact during the cell culture process, eliminating open events and hands-on tasks associated with manual flask-based culture. One study from Baylor College of Medicine Center for Cell and Gene Therapy showed a 99.8% reduction in open events when using Quantum compared to an equivalent flask-based process.²

Expand multiple cell types with Quantum:

• Mesenchymal stem cells (MSCs)
• T cells
• Fibroblasts
• Dendritic cells
• HEK 293T (for viral vector production)

Performance varies by user and is dependent on customer processes and materials.

¹ Data from one report: Tirughana R, Metz MZ, Li Z, et al. GMP production and scale-up of adherent stem cells with a Quantum Cell Expansion System. Mol Ther Methods Clin Dev. 2018;10:48-56.

² Hanley P, Mei Z, Durett A, et al. Efficient manufacturing of therapeutic mesenchymal stromal cells with the use of the Quantum Cell Expansion System. Cytotherapy. 2014;16(8):1048-1058.